Henry Samson was about 16 when he arrived on the Mayflower. He was a cousin of, and in the company of, Edward Tilley and his family. Edward and Agnes Tilley died during the first winter, but Henry survived.

In February of 1636 Henry married Anne Plummer. The two went on to have 9 children. Henry died in 1684, and he and Ann are buried in Cole’s Hill Burial Ground in Plymouth.